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US 9,844,509 B2Granted
High throughput fabrication of nanoparticles
AssigneePfizer Inc.
InventorDavid M. Dewitt
Life of this patent
Estimating the term…
Abstract
This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).
Claims2
A method of preparing nanoparticles comprising:
- (a) providing:
- (i) a first stock solution comprising an active agent and polymers admixed with one or more organic solvents;
- (ii) a second stock solution comprising a surfactant and a solvent in aqueous phase;
- (iii) a third stock solution comprising a water or buffer quench solution;
- and
- (iv) a fourth stock solution comprising an aqueous carrier and beta-cyclodextrin;
- (b) combining a volume of said first stock solution and a volume of said second stock solution to form an emulsification solution;
- (c) emulsifying said emulsification solution;
- (d) combining the emulsion formed in step (c) with a volume of the third stock solution;
- and
- (e) adding a volume of the fourth stock solution to the solution formed in step (d);
- and separating beta-cyclodextrin and dissolved unencapsulated active agent from the resulting solution.
9 more elements
Dependencies are inferred from the claim text.