Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same

A treatment system for cooling subcutaneous lipid-rich cells in a subject, the treatment system comprising:

• an applicator configured to be in thermal communication the subject's skin;
• a control unit having a cooling state and a heating state, the control unit including
• an applicator circulation circuit including
• a supply end in fluid communication with the applicator,
• a return end in fluid communication with the applicator, and
• a mixing reservoir positioned along a flow path of the applicator circulation circuit, the flow path extending between the supply end and the return end,
• a chiller apparatus fluidically coupled to the applicator circulation circuit, the chiller apparatus including a chilled reservoir configured to hold a volume of pre-chilled coolant at a standby temperature that is lower than 0° C.;
• a controller in communication with the control unit and the chiller apparatus, the controller containing instructions that, when executed, causes the controller to:
• command the chiller apparatus to deliver chilled coolant from the chilled reservoir to the mixing reservoir to lower a temperature of coolant contained in the mixing reservoir to a temperature lower than 0° C., and
• command the applicator circulation circuit to deliver the coolant cooled to a temperature lower than 0° C. from the mixing reservoir to the applicator such that the applicator cools target subcutaneous lipid-rich cells of the subject to a temperature lower than 0° C.;
• and
• command the chiller apparatus to deliver chilled coolant to the applicator circulation circuit to cool the coolant in the applicator circulation circuit to keep the target subcutaneous lipid-rich cells at or below 0° C. for a sufficient length of time to disrupt the target subcutaneous lipid-rich cells.

A treatment system for cooling subcutaneous lipid-rich cells in a subject, the treatment system comprising:

• an applicator configured to be in thermal communication the subject's skin and including at least one temperature sensor,
• a control unit having a cooling state and a heating state, the control unit including
• an applicator circulation circuit including
• a supply end in fluid communication with the applicator,
• a return end in fluid communication with the applicator, and
• a mixing reservoir positioned along a flow path of the applicator circulation circuit, the flow path extending between the supply end and the return end,
• a chiller apparatus fluidically coupled to the applicator circulation circuit, the chiller apparatus including a chilled reservoir configured to hold a volume of pre-chilled coolant at a standby temperature that is lower than 0° C.;
• a controller in communication with the at least one temperature sensor and the chiller apparatus, the controller having instructions that, when executed, causes the controller to
• command the chiller apparatus to deliver chilled coolant from the chilled reservoir to the mixing reservoir to lower a temperature of coolant contained in the mixing reservoir to a temperature lower than 0° C., and
• command the control unit based on a temperature measurement from the at least one temperature sensor to deliver the coolant, which is at a temperature lower than 0° C., to the applicator such that the applicator cools target subcutaneous lipid-rich cells of the subject to a temperature lower than 0° C. for a sufficient length of time to disrupt the target subcutaneous lipid-rich cells.