System and method for intraoperative detection of cancer margins using conformal filters in a dual polarization configuration

A system comprising:

• an intraoperative optical diagnostic device configured to detect features of a biological sample comprising:
• an optical separator positioned to receive interacted photons from the biological sample and configured to separate the interacted photons into a first optical path and a second optical path;
• a first conformal filter positioned to receive interacted photons from the first optical path, the first conformal filter having one or more filter stages configured to filter the interacted photons in the first optical path and generate a first filtered component;
• a second conformal filter positioned to receive interacted photons from the second optical path, the second conformal filter having one or more filter stages configured to filter the interacted photons in the second optical path and generate a second filtered component;
• a controller in communication with the first conformal filter and the second conformal filter, the controller being configured to apply one or more voltages to each of the one or more filter stages of the first conformal filter which causes the first conformal filter to conform to a spectral shape associated with a first analyte, and each of the one or more filter stages of the second conformal filter which causes the second conformal filter to conform to a spectral shape associated with a second analyte;
• and
• one or more detectors positioned to receive the first filtered component, the second filtered component or combinations thereof, each of the one or more detectors being configured to detect the first filtered component, the second filtered component, and combinations there and generate image data from the first filtered component, the second filtered component, or combinations thereof;
• a processor connected to each of the one or more detectors and the controller, the processor being configured to analyze the image data and generate images related thereto, the processor further being configured to cause the controller to individually apply voltage to each stage of each of the first conformal filter and the second conformal thereby individually tuning the each of the first conformal filter and second conformal filter;
• and
• a Look Up Table (“LUT”) in communication with the processor, wherein the LUT comprises the one or more voltages associated with each stage of the one or more stages of the first conformal filter and each stage of the one or more stages of the second conformal filter.