Acetyl-CoA carboxylase modulators

A method of controlling fungal pathogens, the method comprising administering to a plant, a seed or soil a composition comprising an effective amount of a compound of Formula I, Formula II, or a salt thereof,

• wherein
• R2 is selected from the group consisting of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, each of which may be optionally substituted with one or more substituents selected from the group consisting of halogen, CH3, OCH3, CF3, OCF3, and CN;
• R3 is selected from the group consisting of hydrogen, CN, ethynyl, CH2N(R9R10), and C(O)N(R9R10), wherein R9 and R10 are each independently selected from the group consisting of hydrogen and alkyl;
• R4 is selected from the group consisting of haloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, each of which may be optionally independently substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, hydroxyalkyl, hydroxyl, N(R9R10), NR11C(O)R12, and O(CO)R13, wherein R9 and R10 are independently selected from the group consisting of hydrogen and alkyl, R11 is selected from the group consisting of hydrogen and alkyl, R12 is alkyl, and R13 is alkyl;
• R5 is selected from the group consisting of hydrogen and alkyl;
• or R4 and R5 together form a fused cycloalkyl or heterocycloalkyl ring having from 5 to 6 ring atoms selected from the group consisting of carbon, nitrogen, and oxygen;
• R6 is selected from the group consisting of alkyl, haloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, each of which may be optionally independently substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, and haloalkoxy;
• or
• R5 and R6 together form a fused cycloalkyl or heterocycloalkyl ring having from 5 to 6 ring atoms selected from the group consisting of carbon, nitrogen, and oxygen;
• and
• E is selected from the group consisting of S, O, N(H), N(CH3), and CH2;
• and wherein in Formula I, R1 is selected from the group consisting of OH and N(R7R8), wherein R7 and R8 are independently selected from the group consisting of hydrogen, OH, and CH3;
• and in Formula II, R1 is selected from the group consisting of a prodrug of a carboxylic acid and a carboxylic acid isostere.