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US 9,840,493 B2Granted
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
AssigneeSutro Biopharma, Inc.
InventorsWenjin Yang, Qun Yin
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Abstract
Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.
Claims9
A compound according to formula I:
- or a salt thereof, wherein:
- Ar is
- V is a single bond, lower alkylene, or —W1—W2—;
- one of W1 and W2 is absent or lower alkylene, and the other is —NH—, —O—, or —S—;
- X1 is —NH—, —O—, or —S—;
- one of Z1, Z2, and Z3 is —N— and the others of Z1, Z2, and Z3 are each independently —CH—;
- and
- R is lower alkyl.
5 more elements
Dependencies are inferred from the claim text.