Recombinant microorganisms and uses therefor
AssigneeLanzatech New Zealand Limited
InventorsMichael Koepke, Sean Simpson, Fungmin Liew, Wendy Yiting Chen
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Abstract
The invention provides recombinant microorganisms and methods for the production of acetone from gaseous substrates. For example, the recombinant microorganism may be modified to express an exogenous thiolase, an exogenous CoA transferase, and an exogenous decarboxylase.
Claims14
A method of producing acetone comprising culturing a recombinant microorganism in the presence of a gaseous substrate comprising one or more of CO, CO2, and H2 to produce acetone, wherein the recombinant microorganism comprises an exogenous thiolase (EC 2.3.1.9), an exogenous CoA transferase (EC 2.8.3.9), and an exogenous decarboxylase (EC 4.1.1.4 or EC 4.1.1.74), wherein the recombinant microorganism is derived from a parental microorganism selected from the group consisting of Clostridium autoethanogenum, Clostridium ljungdahlii, and Clostridium ragsdalei.
Dependencies are inferred from the claim text.