Exosomes and micro-ribonucleic acids for tissue regeneration
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Ke Cheng, Ahmed Ibrahim
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Abstract
Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in turn result in improved cell or tissue viability and/or function.
Claims17
A therapeutic composition comprising a preparation of exosomes harvested from cardiospheres or cardiosphere-derived cells (CDCs) wherein the preparation comprises exosomes comprising microRNAs miR-210 and miR-146a.
A method of treating an individual having damaged cardiac tissue, comprising:
- administering a plurality of exosomes derived from cardiospheres or cardiosphere-derived cells (CDCs) and comprising microRNAs miR-210 and miR-146a to the cardiac tissue of said individual,
- wherein after administration of said plurality of exosomes, viability of the damaged tissue is improved or formation of new tissue is facilitated.
Dependencies are inferred from the claim text.