Host cells with artificial endosymbionts
AssigneeBell Biosystems, Inc.
InventorsCaleb B. Bell, III, Alexey Bazarov
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Abstract
The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.
Claims18
A method of detecting viability of a mammalian cell, comprising the steps of:
- providing the mammalian cell, wherein the mammalian cell contains a magnetotactic bacterium, and imaging the mammalian cell wherein the imaging detects the magnetotactic bacterium whereby the viability of the mammalian cell is detected.
A method of detecting viability of a stem cell, comprising the steps of:
- providing the stem cell, wherein the stem cell contains a magnetotactic bacterium;
- and imaging the mammalian cell wherein the imaging detects the magnetotactic bacterium whereby the viability of the stem cell is detected.
Dependencies are inferred from the claim text.