US 9,827,216 B2 · Nutritional support to prevent and/or mitigate bone marrow toxicity from a cancerous tumor

Abstract

The present invention relates to methods and immunonutritional compositions for preventing or mitigating paralysis of the bone marrow, caused by a tumor or neoplasm, between cycles of and after anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject tumor-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to treatment; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened due to paralysis of the bone marrow, caused by a tumor or neoplasm.

Claims10

Dependent claims

A method of attenuating chemotherapy-induced neutropenia, the method comprising:

administering enterally an immunonutritional composition to a subject having chemotherapy-induced neutropenia, the subject is undergoing an anti-cancer therapy that comprises an aggressive treatment selected from the group consisting of surgery that removes all or part of a tumor, hormonal treatment that induces apoptosis, radiotherapeutic treatment that induces apoptosis, chemotherapeutic treatment that induces apoptosis, and combinations thereof, and the anti-cancer therapy further comprises neoadjuvant chemotherapeutic treatment before the aggressive treatment, and the composition is administered daily to the subject for a time period extending from a first date between ten and three days before the neoadjuvant chemotherapeutic treatment to a second date between ten and seven days after the aggressive treatment,
wherein the composition comprises immuno-enhancing agents comprising L-arginine, omega-3 fatty acids, and nucleotides.

Dependencies are inferred from the claim text.

Nutritional support to prevent and/or mitigate bone marrow toxicity from a cancerous tumor

Life of this patent

Nutritional support to prevent and/or mitigate bone marrow toxicity from a cancerous tumor

Life of this patent

Abstract

Claims10