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US 9,823,364 B2Granted
Beta and alpha emission tomography for three-dimensional autoradiography
AssigneesArizona Board of Regents on Behalf of the University of Arizona, inviCro, LLC
InventorsHarrison H. Barrett, Brian Miller, Yijun Ding, Liying Chen, John William Hoppin, Luca Caucci
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Abstract
The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.
Claims9
A device for imaging a source of particles comprising:
- a particle track detector for recording images of detectable signals generated along particle tracks in an active material, wherein said detectable signals are generated by an interaction of a particle from said source with said active material, wherein said particle comprises a beta particle, alpha particle, a positron or a conversion electron;
- and
- a processor positioned in data communication with said particle track detector, wherein said processor is configured for:
- analyzing a plurality of images of detectable signals generated along particle tracks of a plurality of particles in an active material to determine attributes of said plurality particle tracks;
- and
- reconstructing a 3D image of said source of particles using attributes corresponding to all of said plurality of particles,
- wherein said attributes comprise one or more of a position of a start of a particle track, a direction of travel of a particle at a start of a particle track, and a total energy deposited by a particle along particle track.
4 more elements
A device for imaging a source of particles comprising:
- a particle track detector for recording images of detectable signals generated along particle tracks in an active material, wherein said detectable signals are generated by an interaction of a particle from said source with said active material, wherein said particle comprises a beta particle, alpha particle, a positron or a conversion electron;
- a camera for obtaining a white-light image of a surface of a tissue;
- and
- a processor positioned in data communication with said particle track detector, wherein said processor is configured for:
- analyzing a plurality of images of detectable signals generated along particle tracks of a plurality of particles in an active material to determine attributes of said plurality particle tracks;
- and
- reconstructing a 3D image of said source of particles using attributes corresponding to all of said plurality of particles.
4 more elements
Dependencies are inferred from the claim text.