System for delivering therapeutic agents into living cells and cells nuclei
AssigneeSabag-Rfa Ltd.
InventorDavid Segev
Life of this patent
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Abstract
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties that are designed capable of targeting and/or penetrating cells or other targets of interest and further capable of binding therapeutic agents to be delivered to these cells, and to delivery systems containing same.
Claims34
A phosphate based oligomeric compound, comprising a repeating unit defined by the structure of formula (A):
- and a first linker, which links between the phosphate groups of two of said repeating units (“a splitting linker”), said linker is defined by the structure of formula (B):
- wherein
- Y is a delivery group or a protected delivery group;
- wherein said delivery group is amine, histidine, guanidine, polyguanidine, imidazole, polyimidzole or any combination thereof;
- w , w′ and w″ are each independently an integer between 0 and 10;
- and
- p is an integer between 0 and 10.
A method of delivering a DNA, RNA or combination thereof to a cell, said method comprises contacting said complex of claim, 26 with said cell, thereby delivering said DNA, RNA or combination thereof to said cell.
Dependencies are inferred from the claim text.