Pharmaceutical compositions comprising meloxicam
AssigneeAxsome Therapeutics, Inc.
InventorHerriot Tabuteau
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Abstract
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as pain.
Claims19
A dosage form comprising a complex of meloxicam and a sulfobutyl ether β-cyclodextrin (SBEβCD), and a bicarbonate, wherein the dosage form is an oral dosage form having a shorter Tmax of meloxicam than an otherwise identical reference dosage form that does not contain a SBEβCD or a bicarbonate, and wherein the complex is formed by mixing meloxicam and the cyclodextrin in a solution and drying the solution to form the complex.
Dependencies are inferred from the claim text.