Genetically modified paramyxovirus for treatment of tumor diseases
AssigneeEberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
InventorsUlrich Manfred Lauer, Michael Bitzer, Martina Zimmermann, Sorin Armeanu-Ebinger, Sascha Bossow, Wolfgang Neubert
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Abstract
The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.
Claims15
A genetically modified oncolytic Paramyxovirus which, in reference to the corresponding wild type (wt), comprises in its F gene at least a first genetic modification and in its P gene at least a second genetic modification, wherein through the second genetic modification the nucleotide sequence encoding at least two accessory non-structural proteins encoded by the P gene is modified, and
- wherein at least one of the accessory non-structural proteins is selected from the group consisting of C′, C, Y1, and Y2.
Dependencies are inferred from the claim text.