Systems and methods for ion isolation using a dual waveform
AssigneeThermo Finnigan LLC
InventorsPhilip M. Remes, Michael W. Senko, Jae C. Schwartz
Life of this patent
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Abstract
A mass spectrometer includes a radio frequency ion trap; and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap; supply a first isolation waveform to the radio frequency ion trap for a first duration, and supply a second isolation waveform to the radio frequency ion trap for a second duration. The first isolation waveform has at least a first wide notch at a first mass-to-charge ratio, and the second isolation waveform has at least a first narrow notch at the first mass-to-charge ratio. The first and second isolation waveforms are effective to isolate one or more precursor ions from the ion population.
Claims27
A mass spectrometer comprising:
- a radio frequency ion trap;
- and
- a controller configured to:
- cause an ion population to be injected into the radio frequency ion trap;
- supply a first isolation waveform to the radio frequency ion trap for a first duration, the first isolation waveform having at least a first wide notch at a first mass-to-charge ratio;
- and
- supply a second isolation waveform to the radio frequency ion trap for a second duration, the second isolation waveform having at least a first narrow notch at the first mass-to-charge ratio;
- the first wide notch and the first narrow notch have q values at a target mass-to-charge ratio that differ by not greater than a factor of about 2;
- the first isolation waveform and the second isolation waveform being substantially similar in amplitude;
- and
- the first and second isolation waveforms being effective to isolate one or more precursor ions from the ion population.
A mass spectrometer comprising:
- a radio frequency ion trap;
- and
- a controller configured to:
- cause an ion population to be injected into the radio frequency ion trap;
- supply a first isolation waveform to the radio frequency ion trap for a first duration, the first isolation waveform having at least a first wide notch encompassing a first mass-to-charge ratio;
- and
- supply a second isolation waveform to the radio frequency ion trap for a second duration, the second isolation waveform having at least a first narrow notch encompassing the first mass-to-charge ratio;
- the first wide notch and the first narrow notch have q values at the first mass-to-charge ratio greater than about 0.45;
- the first isolation waveform and the second isolation waveform being substantially similar in amplitude;
- and
- the first and second isolation waveforms being effective to isolate one or more precursor ions from the ion population.
A mass spectrometer comprising:
- a radio frequency ion trap;
- and
- a controller configured to:
- cause an ion population to be injected into the radio frequency ion trap;
- supply a first isolation waveform to the radio frequency ion trap for a first duration, the first isolation waveform having a plurality of wide notches centered at a plurality of target mass-to-charge ratios;
- and
- supply a second isolation waveform to the radio frequency ion trap for a second duration, the second isolation waveform having a plurality of narrow notches centered at the plurality of target mass-to-charge ratios;
- at a given target mass-to-charge ratio, the corresponding wide and narrow notches have q values that differ by not greater than a factor of about 2;
- the first isolation waveform and the second isolation waveform being substantially similar in amplitude;
- and
- the first and second isolation waveforms being effective to isolate a plurality of precursor ions from the ion population.
A mass spectrometer comprising:
- a radio frequency ion trap;
- and
- a controller configured to:
- cause an ion population to be injected into the radio frequency ion trap;
- supply a first isolation waveform to the radio frequency ion trap for a first duration, the first isolation waveform having a plurality of wide notches centered at a plurality of target mass-to-charge ratios;
- and
- supply a second isolation waveform to the radio frequency ion trap for a second duration, the second isolation waveform having a plurality of narrow notches centered at the plurality of target mass-to-charge ratios;
- at a highest target mass-to-charge ratio, the corresponding wide and narrow notches have q values greater than about 0.45;
- the first isolation waveform and the second isolation waveform being substantially similar in amplitude;
- and
- the first and second isolation waveforms being effective to isolate a plurality of precursor ions from the ion population.
Dependencies are inferred from the claim text.