Bioactive heme-haloperoxidase compositions and methods of their use
AssigneeExOxEmis, Inc.
InventorsJackson T. Stephens, Jr., Matthew J. Pete
Life of this patent
Estimating the term…
Abstract
Compositions comprising a heme-haloperoxidase and an amino alcohol effective for killing or inhibiting the growth of pathogenic microorganisms in the presence of a peroxide and halide and methods of use are provided.
Claims33
A composition for killing or inhibiting the growth of pathogenic microorganisms, comprising:
- a mammalian eosinophil peroxidase, a peroxide or a peroxide source, and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine.
A composition for killing or inhibiting the growth of pathogenic microorganisms, comprising:
- a mammalian eosinophil peroxidase;
- a peroxide or a peroxide source;
- a halide;
- and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine, wherein the amino alcohol enhances the microbicidal activity of the eosinophil peroxidase.
A method for killing or inhibiting the growth of pathogenic microorganisms, comprising:
- contacting the microorganisms, in the presence of a peroxide and a halide, with an effective amount of a composition comprising:
- a mammalian eosinophil peroxidase and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine.
A method of treating a microbial infection in a human or animal subject, comprising:
- administering to the site of infection, in the presence of a peroxide and a halide, an effective amount of a composition comprising:
- a mammalian eosinophil peroxidase and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine.
A binary formulation for killing or inhibiting the growth of pathogenic microorganisms comprising:
- (a) a first composition comprising a mammalian eosinophil peroxidase, and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine;
- and
- (b) a second composition comprising a peroxide, wherein the binary formulation is effective for killing or inhibiting the growth of the pathogenic microorganisms when the first composition and the second composition are combined in a single solution and come in contact with the pathogenic microorganisms.
A binary formulation comprising:
- (a) a first composition comprising a mammalian eosinophil peroxidase, a peroxide-producing oxidase, and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine;
- and
- (b) a second composition comprising a substrate for the peroxide-producing oxidase, wherein the binary formulation is effective for killing or inhibiting the growth of the pathogenic microorganisms when the first composition and the second composition are combined in a single solution and come in contact with the pathogenic microorganisms.
A binary formulation comprising:
- (a) a first composition comprising a mammalian eosinophil peroxidase, a peroxide-producing oxidase, and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine;
- and
- (b) a second composition comprising a substrate for the peroxide-producing oxidase, wherein the binary formulation is effective for killing or inhibiting the growth of the pathogenic microorganisms when the first composition and the second composition are each in solution form and are applied concurrently to the pathogenic microorganisms.
A binary formulation comprising:
- (a) a first composition comprising a mammalian eosinophil peroxidase, a peroxide-producing oxidase, and an amino alcohol selected from the group consisting of ethanolamine, diethanolamine, and propanolamine;
- and
- (b) a second composition comprising a substrate for the peroxide-producing oxidase, wherein the binary formulation is effective for killing or inhibiting the growth of the pathogenic microorganisms when the first composition and the second composition are each in solution form and are applied sequentially to the pathogenic microorganisms.
Dependencies are inferred from the claim text.