Chromophoric polymer dots
AssigneeUniversity of Washington through its Center for Commercialization
InventorsDaniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
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Abstract
The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
Claims30
A chromophoric nanoparticle comprising a semiconducting polymer having a plurality of monomeric units, wherein less than 50% of the monomeric units present in the chromophoric nanoparticle are covalently modified with a hydrophilic moiety, wherein at least one of the monomeric units is covalently modified with a hydrophilic functional group suitable for conjugation, wherein at least one of the monomeric units comprises fluorene or a fluorene derivative, and wherein the hydrophilic functional group is independently selected from the group consisting of carboxylic acid or salts thereof, amino, mercapto, aldehyde, ester, carbonyl, phosphate, cyanate, succinimidyl ester, maleimide, and substituted derivatives thereof.
A chromophoric nanoparticle comprising a semiconducting polymer having a plurality of monomeric units, wherein less than 50% of the monomeric units present in the chromophoric nanoparticle are covalently modified with a hydrophilic moiety, and wherein at least one side chain of the monomeric units is covalently modified with a hydrophilic functional group suitable for conjugation, and wherein at least one of the monomeric units comprises fluorene or a fluorene derivative.
Dependencies are inferred from the claim text.