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US 9,809,852 B2Granted
Systems and methods for biological analysis
AssigneeGenapsys, Inc.
InventorsHesaam Esfandyarpour, Hamid Rategh, Meysam R. Barmi, Kosar B. Parizi, Kambiz Kaviani
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Abstract
Provided herein are devices and methods suitable for sequencing, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other biomolecules.
Claims12
A method for nucleic acid sequencing, comprising:
- (a) directing a plurality of particles onto an array of sensors, wherein an individual particle among said plurality of particles comprises a template nucleic acid molecule coupled thereto, wherein said array comprises a plurality of sensors, wherein an individual sensor among said plurality of sensors comprises a transmitter electrode and a receiver electrode, which transmitter electrode or receiver electrode is coupled to at least another individual sensor among said plurality of sensors;
- (b) positioning said individual particle adjacent to said individual sensor;
- (c) performing a primer extension reaction on said template nucleic acid molecule coupled to said individual particle at said individual sensor;
- and
- (d) during or subsequent to performing said primer extension reaction, measuring a signal that is indicative of a change in impedance between said transmitter electrode and receiver electrode.
2 more elements
Dependencies are inferred from the claim text.