Triptolide derivatives and preparation method and use thereof

A triptolide derivative, being a compound of the Formula (I):

• R1=H or OH;
• R2=H or OH;
• R3=H or OH;
• R4=H or OH;
• R5=H or OH;
• R6=H or OH;
• R7=H or OH;
• G is O or NH;
• A is —CO—, —CO—(CH2)n—CO—, —CH═CH—CO—, —CH═CH—(CH2)n—CO—, —CH(OH)-Ph-CO—, CH(OH)-Ph-(CH2)n—CO—, —CH2-Ph-(CH2)n—CO—, —CO—NH—CO—, —CO—NH—(CH2)n—CO—, —CH2—CH═CH—CO—, —CH2—CH═CH—(CH2)n—CO—, —CO—CH2—, —CO—O—(CH2)n—CO—, —SO2-Ph-CO—, or —SO2-Ph-(CH2)n—CO—;
• wherein 1≦n≦14;
• (CH2)n further comprises a substituent selected from straight or branched alkyl, alkenyl, aralkyl, or alkyl aryalkyl, aryl, halogen, group with a heteroatom, heterocycle substituting one or more H in the (CH2)n, the alkyl is selected from methyl, ethyl, propyl, butyl, pentyl, hexyl or heptyl;
• the alkenyl is selected from vinyl, 1-propenyl, allyl, isopropenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1,3-butadienyl, or the E, Z isomers thereof;
• the aralkyl and the alkyl aralkyl is selected from benzyl, diphenylmethyl, tolyl methyl, triphenylmethyl, cinnamyl, phenethyl, styryl, phenylbutyl and neophenyl;
• the aryl is selected from phenyl, diphenyl, tolyl, methylbenzyl, 4,2,6-trimethylphenyl, cumenyl, di(tert-butyl) phenyl, anthryl, indenyl, naphthyl, haloaryl, haloaryl alkylphenoxy, tolyloxy, xylyl alkoxy, 2,4,6-tris tolyloxy and cumene oxy, diphenyl, anilino, toluidino, tosyl, allyl benzyl or phenyl, furanyl, pyridyl, 2-pyridyl (pyridin-2-yl), indol-1-yl, chloromethylbenzyl or phenyl, trifluoromethylbenzyl or phenyl, hydroxybenzyl or phenyl, methoxybenzyl or phenyl, ethoxybenzyl or phenyl, ethoxymethoxybenzyl or phenyl, allyloxybenzyl or phenyl, phenoxybenzyl or phenyl, acetoxybenzyl or phenyl, benzoyloxy benzyl or phenyl, methylthiobenzyl or phenyl, phenylthio benzyl or phenyl, tolylthio benzyl or phenyl, methylaminobenzyl or phenyl, dimethylaminobenzyl or phenyl, ethylaminobenzyl or phenyl, diethylaminobenzyl or phenyl, acetamidobenzyl or phenyl, carboxybenzyl or phenyl, methoxycarbonyl benzyl or phenyl, ethoxycarbonyl benzyl or phenyl, phenoxycarbonyl benzyl or phenyl, chlorophenoxycarbonyl benzyl or phenyl, N-cyclohexylcarbamoyloxy benzyl or phenyl, allyloxycarbonyl benzyl or phenyl, carbamoyl benzyl or phenyl, N-methylcarbamoyl benzyl or phenyl, N,N-dipropyl carbamoyl benzyl or phenyl, N-phenyl-carbamoyl-benzyl or phenyl, nitrobenzyl or phenyl, cyanobenzyl or phenyl, S-benzyl or phenyl, sulfate benzyl or phenyl, phosphonyl benzyl or phenyl, phosphate benzyl or phenyl and morpholino benzyl or phenyl;
• the halogen comprises fluorine, chlorine, bromine or iodine;
• the group with the heteroatom is selected from methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, methylthio, ethylthio, n-propylthio, iso-propylthio, n-butylthio, isobutylthio, tert-butylthio, methylsulfinyl, ethylsulfinyl, isopropyl sulfinyl, methylsulfonyl, ethylsulfonyl, isopropyl sulfonyl;
• the heterocycle is selected from pyridine, quinolone, thiophene, furan, oxazole, tetrazole, thiazole, imidazole, pyrazole, or indole;
• B is an aptamer, and the aptamer is AS1411 or Sgc8c;
• M is O or OH;
• Z is O;
• X is O;
• wherein A is connected with M, Z or X.