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US 9,809,810 B2Granted
Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
AssigneeOhio State Innovation Foundation
InventorsVish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju
Life of this patent
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Abstract
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
Claims10
A method for controlling cell migration comprising the steps of:
- providing an electromagnetic coil having a first end and a second end;
- connecting the electromagnetic coil to a function generator;
- applying a time-varying voltage waveform to the electromagnetic coil;
- inducing a time-varying electric field around the electromagnetic coil;
- placing the electromagnetic coil adjacent to, and without contacting, the location of cancer cells;
- directing the induced electric field along an axis of migration of the cancer cells;
- orientating the placement of the electromagnetic coil to control the direction of the induced electric field;
- and
- reducing the migration of the cancer cells using the induced electric field.
6 more elements
A method for controlling cell migration comprising the steps of:
- providing an electromagnetic coil having a first end and a second end;
- connecting the electromagnetic coil to a function generator;
- applying a time-varying sawtooth voltage waveform to the electromagnetic coil;
- inducing a time-varying electric field around the electromagnetic coil;
- placing the electromagnetic coil adjacent to, and without contacting, the location of cancer cells;
- directing the induced electric field along an axis of migration of the cancer cells, and wherein the induced electric field switches direction along the axis of migration with a non-equal component directed towards or away from a direction of migration;
- orientating the placement of the electromagnetic coil to control the direction of the nonequal component of the induced electric field;
- and
- reducing migration of the cancer cells using the induced electric field.
6 more elements
Dependencies are inferred from the claim text.