Mitogen-activated protein kinase-dependent recombinant vaccinia virus (MD-RVV) and use thereof
AssigneesNational University Corporation Tottori University, The Chemo-Sero-Therapeutic Research Institute
InventorTakafumi Nakamura
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Abstract
This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.
Claims9
A mitogen-activated protein kinase-dependent vaccinia virus, which is deprived of functions of the vaccinia virus growth factor (VGF) and O1L, which does not grow in a normal cell but grows specifically in a cancer cell, and which has oncolytic properties of specifically damaging cancer cells.
Dependencies are inferred from the claim text.