Racemic drug resolution using polymer supported chiral selector
AssigneeCouncil of Scientific and Industrial Research
InventorsSachin Tanaji Mane, Siona Virgil Daniels, Sarika Babasaheb Deokar, Smita Atmaram Mule, Surendra Ponrathnam, Nayaku Nivrati Chavan
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Abstract
The present invention relates to a process for the separation of enantiomers or resolution of racemic mixtures using high surface area core-shell polymer beads. The present invention further relates to a core-shell functionalized polymer comprising a core which comprises copolymer made from monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinyl-benzene, a shell which comprises monomers selected from glycidyl ethers of methacrylate and a chiral selector selected from tartaric acid derivatives and amino acids.
Claims15
A core-shell functionalized polymer comprising:
- i. a core comprising a crosslinked copolymer made from monomers, said monomers selected from vinyl cyanide, vinylidene cyanide, non-aromatic acrylate, ethylene dimethacrylate and divinylbenzene;
- ii. a shell, comprising a polymer made from monomers selected from glycidyl ethers of methacrylate;
- and
- iii. a chiral selector selected from tartaric acid derivatives and amino acids.
Dependencies are inferred from the claim text.