Cachexia treatment
AssigneeXbiotech, Inc.
InventorJohn Simard
Life of this patent
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Abstract
Administration of an antibody that specifically binds IL-1α is useful for treating cachexia and increasing the lifespan of a subject suffering from cachexia.
Claims14
A method of treating cachexia in a human subject suffering from cachexia, the method comprising the step of administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of an anti-interlukin-1 alpha (IL-1α ) antibody (Ab) effective to increase the subject's lean body mass, body weight, appetite, or muscle mass;
- wherein the subject's lean body mass, body weight, appetite, or muscle mass is increased, thereby treating cachexia.
A method of increasing survival of a human subject having cachexia, the method comprising the step of administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of an anti-IL-1α Ab effective to increase the survival of the subject by at least 10% compared to the predicted survival of the subject if the subject were not treated with the pharmaceutical composition.
Dependencies are inferred from the claim text.