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AssigneeEisai R&D Management Co., Ltd.
InventorsToshio Imai, James Bradford Kline, Tetsu Kawano, Luigi Grasso, Yoshimasa Sakamoto, Jared Spidel, Miyuki Nishimura, Kenzo Muramoto, Tatsuo Horizoe
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The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
A monoclonal anti-human CCL20 antibody or an antigen-binding portion thereof, whose heavy chain complementarity determining region 1 (CDR1), complementarity determining region 2 (CDR2), and complementarity determining region 3 (CDR3) and whose light chain CDR1, CDR2, and CDR3 comprise the amino acid sequences of:
A monoclonal antibody whose heavy chain and light chain comprise the amino acid sequences of SEQ ID NO:
Dependencies are inferred from the claim text.