Influenza hemagglutinin antibodies, compositions and related methods

A recombinant nucleic acid comprising a nucleotide sequence encoding an antibody light chain or an antibody heavy chain,

• wherein the antibody light chain comprises:
• (a) the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79 or the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79 with variants such that it is at least 95% identical to the amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, or
• (b) the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81 or the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:
• 81 with variants such that it is at least 98% identical to the amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81;
• and
• wherein the antibody heavy chain comprises:
• (c) the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78 or the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78 with variants such that it is at least 95% identical to the amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78, or
• (d) the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80 or the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80 with variants such that it is at least 90% identical to the amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80.