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US 9,809,642 B2Granted
Transgenic chicken comprising an inactivated immunoglobulin gene
AssigneeCrystal Bioscience Inc.
InventorsPhilip A. Leighton, William Don Harriman, Robert Etches
Life of this patent
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Abstract
A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and targeting vectors for making the same.
Claims11
A chicken primordial germ cell having a genome in which the endogenous heavy chain immunoglobulin locus has been modified by homologous recombination to contain a selectable marker in place of the endogenous JH region of the locus,
- wherein the sequences that flank the selectable marker in the modified heavy chain immunoglobulin locus are the same as or amplified from the chicken primordial germ cell prior to modification.
Dependencies are inferred from the claim text.