ApoE peptide dimers and uses thereof
AssigneeCognosci, Inc.
InventorsMichael P. Vitek, Dale J. Christensen
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Abstract
The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.
Claims14
A peptide dimer comprising a first ApoE peptide and a second ApoE peptide, wherein each of said first and second ApoE peptides is no more than 20 amino acids in length and comprises a sequence selected from the group consisting of CLRVRLASHLRKLRKRLL (SEQ ID NO:
- 15), CAS(Aib)LRKL(Aib)KRLL (SEQ ID NO:
- 16), CLRVRLAS(Aib)LKRLRK(Nitro-Arg)LL (SEQ ID NO:
- 17), and CLRVRLAS(Aib)LRKLR(K-Ac)RLL (SEQ ID NO:
- 18), wherein the first and second ApoE peptides are covalently cross-linked through the cysteine residue at each amino terminus via a bismaleimide linker.
Dependencies are inferred from the claim text.