Methods for increasing red blood cell levels comprising administering BMP9
AssigneeAcceleron Pharma Inc.
InventorsRavindra Kumar, Naga Venkata Sai Rajasekhar Suragani, John Knopf
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Claims17
A method for increasing red blood cell levels or treating anemia in a patient, the method comprising administering to a patient in need thereof a BMP9polypeptide comprising an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO:
- 3, wherein the BMP9 polypeptide binds to ALK1 and increases red blood cell levels when administered to the patient.
A method for increasing red blood cell levels or treating anemia in a patient, the method comprising administering to a patient in need thereof a BMP9 polypeptide comprising an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO:
- 3, wherein the BMP9 polypeptide binds to ALK1 and increases red blood cell levels when administered to the patient, wherein the BMP9polypeptide comprises an amino acid sequence that is identical to the sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.