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US 9,809,632 B2Granted
Universal protein tag for double stranded nucleic acid delivery
AssigneeUniversity of Washington through its Center for Commercialization
InventorsXiaohu Gao, Hong Yan Liu
Life of this patent
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Abstract
Disclosed herein are chimeric proteins that include one or more double stranded nucleic acid binding domains (dsNABD) and one or more polyHis domains, and compositions that further include a therapeutic double stranded nucleic acid and a targeting ligand bound to the therapeutic double stranded nucleic acid, wherein the dsNABD of the chimeric protein is bound to the therapeutic double stranded nucleic acid, and uses of the compositions to treat disease.
Claims12
A chimeric protein, comprising:
- (a) one or more double stranded ribonucleic acid binding domains (dsRBDs), wherein the one or more dsRBDs comprise the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2-36 and 38-80;
- and
- (b) one or more polyHis domains, wherein each polyHis domain comprises at least 6 consecutive histidine residues, and wherein the one or more polyHis domains in total consist of 18 histidine residues.
1 more element
Dependencies are inferred from the claim text.