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US 9,809,620 B2Granted
Prion disease-specific epitopes and methods of use thereof
AssigneeUniversity of Saskatchewan
InventorsKristen Marciniuk, Ryan Taschuk, Scott Napper, Andrew Potter, Neil Cashman
Life of this patent
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Abstract
Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Claims17
A fusion peptide comprising three or more repeats of an immunogenic peptide, wherein the immunogenic peptide is selected from (a) a peptide comprising the sequence GYMLGSAMSRP (SEQ ID NO:17);
- (b) a peptide comprising the sequence VDQYSNQNNF (SEQ ID NO:19);
- or (c) a peptide comprising a sequence corresponding to GYMLGSAMSRP (SEQ ID NO:17) or VDQYSNQNNF (SEQ ID NO:19) from another non-bovine mammalian species,
- wherein one or more of the repeats is in an inverted orientation.
Dependencies are inferred from the claim text.