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US 9,809,614 B2Granted
Synthetic membrane anchors
AssigneeKode Biotech Limited
InventorsNicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
Life of this patent
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Abstract
Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.
Claims4
A method of preparing a synthetic molecule construct of the structure F—S1—S2-L, comprising the steps of:
- reacting a bis(succinimidyl)dicarboxylate with a phosphatidylethanolamine to provide a phosphatidylethanolamide derivative of the structure S2-L;
- and then
- reacting a primary aminoalkyl glycoside of the structure F—S1 with the phosphatidylethanolamide derivative to provide the construct,
- where F is a mono-, di-, tri- or oligo-saccharide;
- S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl;
- S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—;
- and L is the phosphatidylethanolamide.
4 more elements
Dependencies are inferred from the claim text.