Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same

A deuterium-enriched compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Z is H or D, provided that the abundance of deuterium in Z is at least 30%;
• X1 is —CH2—, —C(O)—, or ψ-C(CH3)═N—, where ψ is a bond to the amide nitrogen atom;
• X2 is —N(R1)—, —O—, —(C1-C2)-alkylene-N(R1)—, or —(C1-C2)-alkylene-O—;
• Y1 is a 3-30 membered alkylene or 3-30 membered heteroalkylene, each of which is optionally substituted by one or more R2;
• R1 is hydrogen or —(C1-C4)-alkyl;
• R2 represents independently for each occurrence oxo, —(C1-C6)-alkyl, —(C3-C6)-cycloalkyl, halogen, —(C1-C6)-haloalkyl, hydroxyl, —(C1-C6)-alkoxyl, or —(C1-C6)-hydroxyalkyl;
• or two occurrences of R2 are taken together with the intervening atom or atoms to form a 3-8 membered ring;
• A1 is a protein binding moiety having a molecular weight of less than 2500 g/mol;
• and any hydrogen atom may be optionally replaced with D.