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US 9,809,597 B2Granted
Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsRitwik Burai, Hilal Lashuel, Vidhu Mathur, Anton Wyss-Coray
Life of this patent
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Abstract
Compositions and methods for modulating innate and adaptive immunity and for use in immunotherapy are disclosed. In particular, the invention relates to novel ganciclovir derivatives and methods of using them for the treatment of immune-related disorders, including inflammation, autoimmunity, and infections, and neurological disorders, and cancer.
Claims25
A compound having the formula:
- or a pharmaceutically acceptable salt thereof, wherein R is a propanethiol, 2-[(2-Amino-6-{2- [2-(2-ethoxyethoxy)ethoxy]ethoxy }-6,9-dihydro- 1H-purin-9-yl)methoxy]-1,3-propanediol, or 2-({2-Amino-6[3-(propyldithio)propoxy]-6,9-dihydro-1H-purin-9-yl}methoxy)-1,3-propanediol.
Dependencies are inferred from the claim text.