Isopropyl triazolo pyridine compounds
AssigneeEli Lilly and Company
InventorsChafiq Hamdouchi, Pranab Maiti, Anne Reifel Miller
Life of this patent
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Abstract
The present invention provides a compound of the Formula (I) below: Wherein R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F; R2 is selected from the group consisting of H, O(C1-C3alkyl)R5, CH2CN, and CN; R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN; R4 is selected from the group consisting of H and CH3; R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH; provided that at least one selected from the group consisting of R1, R2, R3 and R4 is H; or a pharmaceutically acceptable salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.
Claims17
A compound which is:
- wherein
- R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F;
- R2 is selected from the group consisting of H, —O(C1-C3alkyl)R5, CH2CN, and CN;
- R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN;
- R4 is selected from the group consisting of H and CH3;
- and
- R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH;
- provided that at least one selected from the group consisting of R1, R2, R3, and R4 is H;
- or a pharmaceutically acceptable salt thereof.
A compound according to formula II
- wherein R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F;
- R2 is selected from the group consisting of H, —O(C1-C3alkyl)R5, CH2CN, and CN;
- R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN;
- R4 is selected from the group consisting of H and CH3;
- R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH;
- provided that at least one selected from the group consisting of R1, R2, R3, and R4 is H;
- and
- R is selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl, C1-4 alkyl-C3-6 cycloalkyl, phenyl, and C1-5 alkylphenyl, or a pharmaceutically acceptable salt thereof.
A method for preparing a compound of Formula I, below,
- or a pharmaceutically acceptable salt thereof, said method comprising de-esterifying a compound of formula II;
- wherein
- R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F;
- R2 is selected from the group consisting of H, —O(C1-C3alkyl)R5, CH2CN, and CN;
- R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN;
- R4 is selected from the group consisting of H and CH3;
- R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH;
- provided that at least one selected from the group consisting of R1, R2, R3, and R4 is H;
- and
- R is selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl, C1-4 alkyl-C3-6 cycloalkyl, phenyl, and C1-5 alkylphenyl to provide a compound of Formula I, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.