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US 9,809,590 B2Granted
Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors
AssigneeArray BioPharma Inc.
InventorsMark Laurence Boys, Robert Kirk DeLisle, Erik James Hicken, April L. Kennedy, David A. Mareska, Fredrik P. Marmsater, Mark C. Munson, Brad Newhouse, Bryson Rast, James P. Rizzi, Martha E. Rodriguez, George T. Topalov, Qian Zhao
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Abstract
Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
Claims29
A compound having the general formula I
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is hetAr1(CH2)m—, hetAr2CH2— or hetAr3CH2;
- hetAr1 is a 6-membered heteroaryl having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (1-4C)alkoxy, halogen, CF3, or (3-6C)cycloalkyl;
- m is 0, 1 or 2;
- hetAr2 is a 5-membered heteroaryl ring having 2-3 ring heteroatoms independently selected from N and S where at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
- hetAr3 is a bicyclic 5,6-fused heteroaryl ring having two ring nitrogen atoms;
- R2 is CH3;
- R3 is H;
- R4 is H;
- R5 is hetCyc4(1-4C)alkoxy or hetCyc5(1-4C)alkoxy;
- hetCyc4 is a 4-7 membered heterocycle having 1-2 ring heteroatoms independently selected from N, O and S, wherein one of said ring nitrogen atoms is optionally oxidized to N(O) and wherein said S ring atom is optionally oxidized to SO or SO2, wherein hetCyc4 is optionally substituted with one or more substituents independently selected from halogen, OH, (1-6C)alkyl, (1-4C alkoxy)(1-6C)alkyl, (1-4C)alkyl-OC(═O)— and (1-6C)alkoxy;
- hetCyc5 is a spiro heterocycle having 2 ring heteroatoms independently selected from N and O, wherein hetCyc5 is optionally substituted with a group selected from (1-6C)alkyl;
- and
- R6 is H.
11 more elements
Dependencies are inferred from the claim text.