Aminoester derivatives

A compound of formula (I):

• wherein:
• each R1 is hydrogen halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, hydroxy, —SO2NR6R7, —CN, —NR8SO2R9, —NR6R7, —CONR6R7, or —NR8COR9, wherein said (C1-C4) alkyl is optionally substituted by one or more groups selected from the group consisting of (C3-C7) cycloalkyl, hydroxyl, and —NR6R7 and wherein said (C1-C4) alkoxy is optionally substituted by one or more halogens or (C3-C7) cycloalkyl groups, wherein
• R6 is hydrogen or (C1-C6) alkyl;
• R7 is hydrogen or (C1-C6) alkyl;
• R8 is hydrogen or (C1-C6) alkyl;
• R9 is hydrogen or (C1-C6) alkyl;
• n is an integer of 1 to 3;
• each R2 is hydrogen halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4)haloalkyl, hydroxy, —SO2NR10R11, —CN, or —NR12SO2R13, wherein said (C1-C4) alkyl and said (C1-C4) alkoxy are optionally substituted by one or more (C3-C7) cycloalkyl groups, wherein
• R10 is hydrogen or (C1-C6) alkyl;
• R11 is hydrogen or (C1-C6) alkyl;
• R12 is hydrogen or (C1-C6) alkyl;
• R13 is hydrogen or (C1-C6) alkyl;
• m is an integer of 1 to 3;
• R3 and R4 are different or the same and are independently:
• H;
• (C3-C7) cycloalkylcarbonyl;
• (C1-C6) alkyl, optionally substituted by one or more substituents selected from the group consisting of (C1-C4 alkoxy), (C3-C7) cycloalkyl, and (C5-C7) cycloalkenyl;
• (C1-C6) haloalkyl;
• (C3-C7) cycloalkyl;
• (C5-C7) cycloalkenyl;
• (C2-C6) alkenyl;
• or
• (C2-C6) alkynyl;
• each R5, whenever present, is independently CN, NO2, CF3, or a halogen atom;
• k is 0 or an integer of 1 to 3;
• L1 is a bond
• W1 is a heteroarylene group;
• W2 is aryl or heteroaryl;
• L2 is a group —(CH2)q— wherein q is an integer of 1 to 4;
• L3 is a bond or a group —(CH2)s— wherein s is 1 or 2;
• X is:
• wherein
• R20 is H, OH, or (C1-C4) alkyl optionally substituted by one or more hydroxyl group;
• R21 is hydrogen or (C1-C6) alkyl optionally substituted by hydroxyl;
• i is 1 or 2;
• i′ is 1 or 2;
• i″ is an integer of 1 to 4;
• A is:
• a group (CH2)s—NR16R17 wherein s is an integer of 1 to 4 and R16 and R17 are independently hydrogen or (C1-C4) alkyl;
• or
• a saturated monocyclic, bicyclic, or tricyclic heterocyclic ring system containing one N heteroatom or NR18 wherein R18 is (C1-C4) alkyl or benzyl;
• an N-oxide on the pyridine ring, a deuterated derivative, or a pharmaceutically acceptable salt thereof.