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US 9,809,580 B2Granted
Carboxylic acid compound, method for preparation thereof, and use thereof
AssigneeInventisBio Shanghai Ltd.
InventorYueheng Jiang
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Abstract
The present invention relates to the technical field of medicine, and specifically relates to the carboxylic acid compound represented by the chemical formula I or chemical formula II, and a pharmaceutically acceptable salt, a prodrug, and a solvate thereof, and a method for preparation thereof, as well as a pharmaceutical composition containing the described substances, and a use thereof.
Claims20
A carboxylic acid compound of Chemical Formula Ia or Ib or Chemical Formula IIa or IIb, or a pharmaceutically acceptable salt, or solvate thereof,
- wherein,
- Y, W and Z are each independently C or N;
- A is S or O;
- Q is substituted or unsubstituted ethylene, propylene,
- or phenylene, wherein substituent is methyl, ethyl, propyl, —CD3, cyclopropyl, cyclobutyl, cyclopentyl, cyclopropylidene, cyclobutylidene, cyclopentylidene or fluorine;
- M is H, Na, K, Ca or C1-4 alkyl;
- R1, R2 and R3 are each independently hydrogen or halogen;
- Ra and Rb are each independently hydrogen, C1-6 alkyl or bond to each other to form a substituted or unsubstituted C6-10 aromatic ring structure, wherein the substituent in the substituted C6-10 aromatic ring structure is halogen, C1-3 alkyl or C1-3 alkoxy;
- Rc is —CN, carboxyl, hydroxyl-substituted or unsubstituted C1-6 alkyl, hydroxyl-substituted or unsubstituted C3-6 cycloalkyl, hydroxyl-substituted or unsubstituted 3- to 6-membered heterocycloalkyl containing 1 to 3 heteroatom(s) selected from O, S and N.
6 more elements
Dependencies are inferred from the claim text.