Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors

A compound of Formula I:

• or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein:
• X is O, S, NH or N—CN;
• Ring A is
• R1 is phenyl optionally substituted with one or more substituents independently selected from halogen and (1-3C)alkyl;
• R2 is (1-3C)alkyl optionally substituted with 1 to 5 fluoros or (3-4C)cycloalkyl optionally substituted with one or two fluoros;
• R6 is H or CH3;
• Ring C is formula C-1
• R3 is (1-6C)alkyl, hydroxy(1-6C)alkyl, Ar2, hetCyc1, (3-7C)cycloalkyl, or hetAr2;
• Ar2 is phenyl optionally substituted with one or more substituents independently selected from halogen and (1-6C)alkyl;
• hetCyc1 is a 5-6-membered saturated or partially unsaturated heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O;
• hetAr2 is a 5-6 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S and optionally substituted with one or more substituents independently selected from (1-6C)alkyl and halogen;
• R4 is hetAr4, hetAr5 or hydroxy(1-6C)alkoxy;
• hetAr4 is a 5-6 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, S and O and substituted with one or more substituents independently selected from (1-6C)alkyl, halogen, CN, hydroxy(l-6C)alkyl, trifluoro(1-6C)alkyl, difluoro(1-6C)alkyl, fluoro(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C cycloalkyl)CH2— (3-6C cycloalkyl)C(═O)—, (1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkylsulfonyl, NH2, (1-6C alkyl)amino, di(1-6C alkyl)amino, (1-3C trifluoroalkoxy), fluoro(1-6C alkyl)amino, difluoro(1-6C alkyl)amino, trifluoro(1-6C alkyl)amino, and (3-4C cycloalkyl)amino;
• hetAr5 is a group selected from the structures:
• where Rz is (3-4C)cycloalkyl or (1-3C)alkyl optionally substituted with 1-3 fluoros, wherein each of said hetAr5 groups is optionally further substituted with one or more substituents independently selected from F and (1-3C)alkyl optionally substituted with 1-3 fluoros;
• and
• R5 is (1-6C)alkyl, monofluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, tetrafluoro(2-6C)alkyl, pentafluoro(2-6C)alkyl, halogen, CN, (1-4C)alkoxy, hydroxy(1-4C)alkyl, (1-3C alkoxy)(1-4C)alkyl, (1-4C alkyl)OC(═O)—, (1-6C)alkylthio, (3-4C)cycloalkyl, amino, aminocarbonyl, trifluoro(1-3C alkyl)amido, or phenyl optionally substituted with one or more substituents independently selected from halogen, (1-6C)alkyl and (1-6C)alkoxy;
• or
• R4 and R5 together with the atoms to which they are attached form a 5-6 membered saturated, partially unsaturated or unsaturated carbocyclic ring optionally substituted with one or more substituents independently selected from (1-6C)alkyl, or
• R4 and R5 together with the atoms to which they are attached form 5-6 membered saturated, partially unsaturated or unsaturated heterocyclic ring having a ring heteroatom selected from N, O or S, wherein said heterocyclic ring is optionally substituted with one or two substituents independently selected from (1-6C alkyl)C(═O)O—, (1-6C)acyl, (1-6C)alkyl and oxo, and said sulfur ring atom is optionally oxidized to S(═O) or SO2.