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US 9,809,573 B2Granted
Substituted pyridine derivatives useful as GSK-3 inhibitors
AssigneeBristol-Myers Squibb Company
InventorsGuanglin Luo, Ling Chen, Gene M. Dubowchik, Swanee E. Jacutin-Porte, Prasanna Sivaprakasam, John E. Macor
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Abstract
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
Claims3
A compound of formula I
- where:
- R1 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl alkylcycloalkyl, dialkylcycloalkyl, phenylcycloalkyl, hydroxycycloalkyl, or ketocycloalkyl;
- R2 is hydrogen or alkyl;
- R3 is hydrogen or alkyl;
- or N(R2)(R3) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or azabicycloheptane, and is substituted with 0-4 halo or alkyl substituents;
- Ar1 is 3-pyridinyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, hydroxyalkyl, (hydroxyl)haloalkyl, alkoxyalkyl, (N(R2)(R3))alkyl, benzyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, (hydroxyl)alkoxy, (alkoxy)alkoxy, (cycloalkyl)alkoxy, phenoxy, alkylcarbonyl, (haloalkyl)carbonyl, phenylcarbonyl, alkoxycarbonyl, carboxy, aminocarbonyl, acetamido, N(R2)(R3) and Ar2;
- and
- Ar2 is phenyl, naphthalenyl, pyrrolyl, furanyl, thienyl, pyrrazolyl, imidazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl, and is substituted with 0-1 substituents selected from the group consisting of cyano, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylcarbonyl, and N(R2)(R3);
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.