Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
AssigneeSuzhou Zelgen Biopharmaceuticals Co., Ltd.
InventorsBinhua Lv, Chengwei Li, Benwen Cao, Xudong Pang
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Abstract
Deuterated diaminopyrimidine compounds and pharmaceutical compositions containing such compounds are described. In particular, disclosed are deuterated diaminopyrimidine compounds of formula (I), and pharmaceutical compositions containing such compounds or crystal forms, pharmaceutically acceptable salt, hydrates or solvates thereof. The disclosed deuterated diaminopyrimidine compounds can be used for treating and/or preventing protein kinase-associated diseases, such as cell proliferative disease, cancer, immune disease and the like.
Claims16
A deuterated diaminopyrimidine compound, or a crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof of formula (I):
- wherein:
- R1a, R1b, R1c, R2a, R2b, R2c, R3, R4, R5, R6, R7, R9, R10, R11, R12, R13a, R13b, R13c, R14a, R14b, R14c, R15a, R15b, R15c, R16, R17a, R17b, R18a, R18b, R19a, R19b, R20a and R20b are independently hydrogen, deuterium or halogen;
- R8 is halogen;
- with the proviso that at least four of R1a, R1b, R1c, R2a, R2b, R2c, R3, R12, R13a, R13b, R13c, R14a, R14b, R14c, R19a, R19b, R20a and R20b are deuterium.
Dependencies are inferred from the claim text.