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US 9,809,560 B2Granted
Ligands and methods for labeling biomolecules in vivo
AssigneeAlbert Einstein College of Medicine
InventorsPeng Wu, David Soriano del Amo, Wei Wang, Florence L. Marlow
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Abstract
Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.
Claims9
A composition comprising a ligand for use in an azide-alkyne cycloaddition reaction and CuSO4, wherein the ligand is in complex with CuSO4 in a ratio of ligand:CuSO4 of at least 2:1 and wherein the ligand comprises a tris(triazolylmethyl)amine of formula (I):
- wherein R1 and R2 are
- wherein R3 is
- wherein n2 is 2-3, and n4 is 1-2;
- and wherein ( ) is the point of attachment of the R1, R2, or R3 group to the ring structure.
1 more element
A compound selected from the group consisting of
A compound having the structure of formula (I):
- wherein R1 and R2 are
- wherein R3 is
- wherein n2 is 2-3, and n4 is 1-2;
- and wherein ( ) is the point of attachment of the R1, R2, or R3 group to the ring structure.
1 more element
Dependencies are inferred from the claim text.