Isoquinoline compounds, a process for their preparation, and pharmaceutical compositions containing them

A compound of formula (I):

• wherein:
• X represents —C(═O), —CH(OH)— or —CH2—,
• Ri1 represents a hydrogen atom or a hydroxyl group,
• it being understood that the compound of formula (I) wherein Ri1 represents a hydroxyl group may be represented by the following tautomeric form:
• Ri2 and Ri3, which may be identical or different, each represent a hydrogen atom, a (C1-C6)alkyl group or a halogen atom,
• Ri6, Ri7 and Ri8, which may be identical or different, each represent a hydrogen atom or a halogen atom,
• Ra1 and Ra5, which may be identical or different, each represent a hydrogen atom, a halogen atom, an —O(C1-C6)alkyl group or a (C1-C6)alkyl group,
• Ra2 represents a hydrogen or halogen atom, a hydroxyl group, a —O(C1-C6)alkyl group, a —(C1-C6)alkyl group, a nitrogen-containing heterocycle having from 3 to 7 ring members, or —O—(CH2)m—NR′R″,
• Ra3 represents a hydrogen atom, an —O(C1-C6)alkyl group, a —(C1-C6)alkyl group, a nitrogen-containing heterocycle having from 3 to 7 ring members, or —CRy1Ry2NH(Ry3),
• Ra4 represents a hydrogen atom a halogen atom, an —O(C1-C6)alkyl group, a —(C1-C6)alkyl group, or —CRy1Ry2NH(Ry3),
• it being understood that:
• Ra1, Ra2, Ra3, Ra4 and Ra5 may not simultaneously represent a hydrogen atom,
• Ra3 and Ra4 may not simultaneously represent —CRy1Ry2NH(Ry3),
• Ra1 and Ra2, together with the carbon atoms carrying them, may form a heterocycle having from 4 to 7 ring members chosen from tetrahydrofuran, 1,4-dioxane, tetrahydropyran, tetrahydro-2H-pyran-4-amine and 1-(tetrahydro-2H-pyran-4-yl)methanamine, and
• Ra2 and Ra3, together with the carbon atoms carrying them, may form a hydrocarbon ring having from 4 to 7 ring members chosen from cyclopentane, cyclopentanamine, N-cyclopentylglycinamide and 1-methylcyclopentanamine,
• m is an integer, the value of which is fixed at 1, 2 or 3,
• R′ and R″, which may be identical or different, each represent —(C1-C6)alkyl groups or, together with the nitrogen atom carrying them, form a heterocycle having from 3 to 7 ring members,
• Ry1 represents a hydrogen atom, a —(C1-C6)alkyl group, a —CH2-cyclohexyl group, or a 3-methoxyphenyl group,
• Ry2 represents a hydrogen atom or a —(C1-C6)alkyl group,
• Ry3 represents:
• a hydrogen atom,
• —C(═O)—CHRy4-NHRy5 wherein Ry4 represents a hydrogen atom or a (C1-C6)alkyl group and Ry5 represents a hydrogen atom or a methyl group, or
• a —(C1-C6)alkyl group which may be substituted by a hydroxyl group, an —O(C1-C3)alkyl group, a cyclohexyl group or a methylsulphonyl group,
• or Ry1 and Ry2, together with the carbon atom carrying them, form a cyclopropane, cyclobutane or tetrahydropyran group,
• or Ry2 and Ry3, together with the carbon and nitrogen atoms carrying them, respectively, form a pyrrolidine or piperidine group,
• or an optical isomer thereof, where it exists, an addition salt thereof with a pharmaceutically acceptable acid or a hydrate thereof.