Quinolyl hydrazones for the treatment of tuberculosis and related diseases
AssigneeTecnimede Sociedade Tecnico-Medicinal S.A.
InventorsAna Lucia Almeida Ferreira, Ana Sofia Lopes, Augusto Eugenio Pardal Filipe, Pedro Filipe Eufrasio Pedroso, Susana Marques De Almeida Pecorelli, Carlos Caixado
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Abstract
The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.
Claims13
A method of treatment of infections caused by one or more of Mycobacterium tuberculosis Complex (MTbC), Mycobacterium leprae, and nontuberculous mycobacteria (NTM), comprising administering to a mammal an amount of a pharmaceutical composition comprising at least a compound of general Formula (I):
- (I)
- wherein Q is
- and A is a 5-6 member substituted or unsubstituted aryl or heteroaryl ring selected from:
- wherein
- R1, R2 and R3 are each independently of one another, hydrogen, (C1-C4)alkyl, hydroxyl, halogen, methoxy or methoxy-acetic acid;
- and
- R4, R5, R6 and R7 are each independently of one another, hydrogen or (C1-C4)alkyl,
- or a pharmaceutically acceptable salt, ester, solvate, isomer or prodrug thereof.
Dependencies are inferred from the claim text.