Back to results
US 9,809,546 B2Granted
Process for producing diamine derivative
AssigneeChungwha Chemical Synthesis & Biotech Co., Ltd.
InventorsTzu-Chiang Lu, Chien-Yi Chen, Ching-Shuen Cheng, Chin-Cheng Mai
Life of this patent
Estimating the term…
Abstract
The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).
Claims9
A process for producing a compound of formula (D):
- comprising the following steps:
- step 1:
- placing a HCl salt of formula (C) into an organic solvent containing dimethyl sulfoxide or dimethylformamide and treating with a di(C1-C4 alkyl)amines:
- step 2:
- adding a compound of formula (A) or a salt or a salt hydrate thereof into the mixture of step 1:
- and
- step 3:
- crystallizing the mixture processed in step 2.
5 more elements
Dependencies are inferred from the claim text.