Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof
AssigneeShuttle Pharmaceuticals, Inc.
InventorsScott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
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Abstract
Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
Claims6
A compound of the formula:
- for a pharmaceutically acceptable salt thereof.
A pharmaceutical formulation, in unit dosage form, comprising a compound in an amount effective to inhibit histone deacetylase (HDAC) and activate ataxia telangiectasia mutated (ATM) in a patient in need thereof and at least one physiologically compatible carrier medium, wherein the compound is selected from the group consisting of
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.