Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone
AssigneeSyngenta Participations AG
InventorHelmars Smits
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Abstract
The invention relates to a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III R1M2X (III), wherein R1 is CI-C4alkyl; M2 is Li or Mg and X is halogen or absent; with a compound of formula IV CF3—C(O)—R2 (IV), wherein R2 is halogen, hydroxyl, CI-C4alkoxy, (di-CI-C4alkyl)amino, OC(O)CF3, phenoxy or OM1; wherein M1 is Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.
Claims8
A process for the preparation of the compound of formula I
- comprising
- a) reacting the compound of formula II
- in the presence of magnesium or an organometallic reagent of formula III
- R1—M2X (III),
- wherein
- R1 is C1-C4alkyl;
- M2 is Lithium or Magnesium and
- X is halogen or absent;
- with a compound of formula IV
- CF3—C(O)—R2 (IV),
- wherein R2 is halogen, hydroxyl, C1-C4alkoxy, (di-C1-C4alkyl)amino, OC(O)CF3, phenoxy or OM1;
- wherein
- M1 is Lithium, Magnesium, Sodium or Potassium;
- to the compound of formula V,
- and
- b) reacting the compound of formula V with an alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.
Dependencies are inferred from the claim text.