High throughput membrane with channels

A polymeric microporous filtration membrane comprising:

• (a) a first microporous surface;
• (b) a second microporous surface;
• and
• (c) first and second layers integrally bonded to one another, the first layer including the first microporous surface and having a first layer thickness, and the second layer comprising the second microporous surface and having a second layer thickness;
• and
• (i) the first layer comprises at least first and second sets of different controlled pore structures, and at least one additional set of controlled pore structures, the additional set of pore structures having a smaller average pore size than the second set of pore structures, the additional set of pore structures having an average pore size in the range of about 0.3 μm to about 5 μm, the first set of controlled pore structures comprising channels comprising an aspect ratio of length/diameter of at least about 4, wherein the first and second sets of different controlled pore structures, and the additional set of pore structures, are intermixed within the first layer thickness;
• and
• (ii) the second layer comprises a third set of controlled pore structures, wherein the third set of pore structures has a smaller average pore size than the second set of pore structures, wherein the third set of controlled pore structures has an average pore size of at least about 0.1 μm, wherein the second layer does not include controlled pore structures comprising channels in the second layer thickness.