Post procedure skin care gel and methods of use thereof
AssigneeJan Marini Skin Research
InventorsJan Marini, Subhash J. Saxena
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Abstract
Compositions and methods are provided for a post-procedure care following the treatment of skin with cosmetic skin resurfacing treatments, which include without limitation a variety of laser treatments, chemical peeling and dermabrasion, by applying a silicone-based gel formulation in combination with therapeutic peptides. Peptides of interest include one or more of transforming growth factor, epidermal growth factor, and basic fibroblast growth factor. The formulation may further comprise an effective dose of one or more acylated peptides, which peptides are active in remodeling of the skin.
Claims12
A method for post-procedure treatment following a skin resurfacing procedure, comprising:
- topically applying to the skin of the subject following the skin resurfacing procedure from 1 to 100 ml. of a silicone-based gel comprising:
- from 85% to 95% of the total volume cyclic dimethyl polysiloxane;
- Transforming growth Factor (TGFβ1) at a concentration of from 1 to 50 μg/ml;
- Epidermal Growth Factor (EGF) at a concentration of from 1 to 50 μg/ml;
- and Basic Fibroblast Growth Factor (FGF) at a concentration of from 0.5 to 25 μg/ml;
- Palmitoyl-Gly-His-Lys and SEQ ID NO:
- 1 Palmitoyl-Gly-Glu-Pro-Arg at a concentration of from 0.5% to 5% by weight;
- in a cosmetically acceptable vehicle.
A method for post-procedure treatment following a facial skin resurfacing procedure, comprising:
- topically applying to the facial skin of the subject within 6 hours of the skin resurfacing procedure from 1 to 100 ml. of a silicone-based gel comprising:
- from 60% to 85% of the total volume cyclopentasiloxane and 1-25% of the total volume cyclohexasiloxane;
- TGFβ1 at a concentration of from 1 to 50 μg/ml;
- EGF at a concentration of from 1 to 50 μg/ml;
- and FGF at a concentration of from 0.5 to 25 μg/ml;
- Palmitoyl-Gly-His-Lys and SEQ ID NO:
- 1 Palmitoyl-Gly-Glu-Pro-Arg at a concentration of from 0.5% to 5% by weight;
- in a cosmetically acceptable vehicle.
Dependencies are inferred from the claim text.