System and method for non-invasive neuronal stimulation
AssigneeEBS Technologies GmbH
InventorsIngo Wundrich, Udo Warschewske
Life of this patent
Estimating the term…
Abstract
The invention relates to a system for electrical and/or magnetic neuronal stimulation, comprising a signal generator for generating a stimulation signal, in particular an alternating-current stimulation signal, an applicator for applying the stimulation signal, in particular in an area on or directly around the optic nerve, a lead for deriving a measurement signal, in particular an EEG signal, a biomarker calculation unit for calculating a biomarker based on the measurement signal, and an optimization unit, in particular for performing a stochastic optimization process, for optimizing the value of the biomarker by varying the stimulation signal.
Claims44
A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
- deriving a measurement signal from at least one electrode in electrical communication with the patient,
- generating a stimulation signal,
- applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation,
- determining a biomarker from the measurement signal, and
- varying the stimulation signal in dependence on the biomarker,
- wherein the biomarker is functionally dependent on the measurement signal, and wherein the method further comprises the step of:
- determining the functional dependence of the biomarker by machine learning using training data from test subjects.
A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
- deriving a measurement signal from at least one electrode in electrical communication with the patient,
- generating a stimulation signal,
- applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation,
- determining a biomarker from the measurement signal, and
- varying the stimulation signal in dependence on the biomarker,
- wherein the method further comprises the step of:
- carrying out an optimization method during the stimulation to maximize the biomarker by way of a variation of parameters of the stimulation signal.
A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
- deriving a measurement signal from at least one electrode in electrical communication with the patient, the measurement signal including items of amplitude, frequency, and/or phase information,
- generating a stimulation signal,
- applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation,
- determining a biomarker from the measurement signal, and
- varying the stimulation signal in dependence on the biomarker,
- wherein the method further comprises the step of:
- ascertaining the amplitude, frequency, and/or phase information of the measurement signal in a specific time range after the application of a pulse of the stimulation signal.
A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
- deriving a measurement signal from at least one electrode in electrical communication with the patient,
- generating a stimulation signal,
- applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation,
- determining a biomarker from the measurement signal, and
- varying the stimulation signal in dependence on the biomarker,
- wherein the method further comprises the steps of:
- generating first signals having a high proportion of noise and
- second signals having a low proportion of noise and
- applying the first and second signals in different regions of the patient and/or using different electrodes.
A noninvasive electrical and/or magnetic stimulation method for neuronal stimulation of a patient comprising the steps of:
- deriving a measurement signal from at least one electrode in electrical communication with the patient,
- generating a stimulation signal,
- applying the stimulation signal by means of electrodes, i.e., electrical and/or magnetic stimulation, wherein the applying step includes the step of successively applying as the stimulation signal a plurality of predefined stimulation sequences,
- determining a biomarker from the measurement signal following each application of the plurality of predefined stimulation sequences,
- varying the stimulation signal in dependence on the biomarker,
- carrying out an optimization method during the stimulation, the optimization method providing an optimal value of the biomarker, and
- subsequently performing further stimulation using the stimulation sequence with which the optimum value of the biomarker was achieved.
Dependencies are inferred from the claim text.