Regenerative peripheral nerve interface
AssigneesThe Regents of the University of Michigan, University of Delaware
InventorsPaul S. Cederna, Melanie G. Urbanchek, David C. Martin
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Abstract
The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.
Claims23
A regenerative peripheral nerve interface (RPNI) for a subject comprising:
- an insulating substrate and at least one metallic electrode disposed on or in the insulating substrate, so that the insulating substrate and the at least one metallic electrode define a thin-film array;
- a layer of decellularized biotic material comprising decellularized small intestinal submucosa (SIS);
- and
- at least one conductive polymer.
A method of forming a regenerative peripheral nerve interface, the method comprising:
- forming at least one metallic electrode in or on an insulating substrate, wherein the at least one metallic electrode and the insulating substrate define a thin-film array;
- depositing a first layer of a conductive polymer onto a first portion of a surface of the at least one metallic electrode;
- and
- coating a second portion of the surface of the at least one metallic electrode with a layer of decellularized biotic material comprising decellularized small intestinal submucosa (SIS) to form the regenerative peripheral nerve interface.
A regenerative peripheral nerve interface device for interfacing between a peripheral nerve of a subject and a prosthetic device, the regenerative peripheral nerve interface device comprising:
- an insulating substrate;
- at least one metallic electrode disposed in or on the insulating substrate defining a thin-film array, a portion of a surface of the at least one metallic electrode having a layer of a first conductive polymer;
- a layer of decellularized small intestinal submucosa (SIS) coating a portion of the surface of the at least one metallic electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form a regenerative peripheral nerve interface;
- and
- a layer of muscle tissue contacting the regenerative peripheral nerve interface.
Dependencies are inferred from the claim text.