Drug delivery device with tamper-evident closure means

A drug delivery device for administering a dose of a medicament by way of injection, the device comprising:

• a housing to receive a cartridge at least partially filled with a medicament and being sealed with a piston slidably disposed therein,
• a drive mechanism having a piston rod to be displaced in a distal direction to operably engage with the piston of the cartridge,
• a dose button operably engaged with the drive mechanism for at least one of preparing and initiating a dose dispensing action of the drive mechanism, and
• a protective member adapted to impede actuation of the dose button, wherein the protective member is releasably connected to the housing via a breakable seal, and wherein the protective member comprises a threaded section that mates with a threaded section of the housing such that the protective member is threadedly engaged with the housing in at least an initial configuration,
• wherein the seal comprises a first ring member and a second ring member, wherein the first ring member is positively engaged or frictionally engaged, integrally joined or firmly bonded to the housing in the initial configuration and the second ring member is positively engaged or frictionally engaged, integrally joined or firmly bonded to the protective member such that the first ring member and the second ring member are concentrically arranged with respect to each other, sharing a center in the initial configuration, and wherein the first ring member comprises a number of ring segments interconnected by predetermined breaking points and being individually connected to the second ring member, and wherein the first ring member disintegrates into the ring segments along the predetermined breaking points when the first ring member becomes subject to at least one of a radially directed force effect and an axially directed force effect.